Severin S E, Boldyrev A A, Stvolinskiĭ S L, Bordiukov M M, Goncharenko E N, Deev L I, Malinina I E, Kudriashov Iu B
Radiobiologiia. 1990 Nov-Dec;30(6):765-8.
The influence of carnosine (beta-alanyl-l-histidine) on the survival rate of albino mice subjected to whole-body X-irradiation has been investigated. Carnosine (50-200 mg/kg/day) administered per os during a period of 20 days before irradiation (5.0 Gy) increased the survival rate by 45-65%, whereas the administration of carnosine within 30 days after irradiation (5.5 Gy) produced an insignificant protective effect and caused inhibition of the postirradiation histamine accumulation in the spleen.
已研究了肌肽(β-丙氨酰-L-组氨酸)对接受全身X射线照射的白化小鼠存活率的影响。在照射(5.0 Gy)前20天经口给予肌肽(50 - 200 mg/kg/天)可使存活率提高45 - 65%,而在照射(5.5 Gy)后30天内给予肌肽产生的保护作用不显著,并导致照射后脾脏中组胺积累受到抑制。