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[肌肽的辐射修饰特性]

[The radiation modifying properties of carnosine].

作者信息

Severin S E, Boldyrev A A, Stvolinskiĭ S L, Bordiukov M M, Goncharenko E N, Deev L I, Malinina I E, Kudriashov Iu B

出版信息

Radiobiologiia. 1990 Nov-Dec;30(6):765-8.

PMID:2270276
Abstract

The influence of carnosine (beta-alanyl-l-histidine) on the survival rate of albino mice subjected to whole-body X-irradiation has been investigated. Carnosine (50-200 mg/kg/day) administered per os during a period of 20 days before irradiation (5.0 Gy) increased the survival rate by 45-65%, whereas the administration of carnosine within 30 days after irradiation (5.5 Gy) produced an insignificant protective effect and caused inhibition of the postirradiation histamine accumulation in the spleen.

摘要

已研究了肌肽(β-丙氨酰-L-组氨酸)对接受全身X射线照射的白化小鼠存活率的影响。在照射(5.0 Gy)前20天经口给予肌肽(50 - 200 mg/kg/天)可使存活率提高45 - 65%,而在照射(5.5 Gy)后30天内给予肌肽产生的保护作用不显著,并导致照射后脾脏中组胺积累受到抑制。

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引用本文的文献

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Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts.肌肽抑制碳酸酐酶IX介导的细胞外酸中毒并抑制HeLa肿瘤异种移植物的生长。
BMC Cancer. 2014 May 22;14:358. doi: 10.1186/1471-2407-14-358.
2
Effects of beta-alanine on muscle carnosine and exercise performance: a review of the current literature.β-丙氨酸对肌肉肌肽和运动表现的影响:当前文献综述。
Nutrients. 2010 Jan;2(1):75-98. doi: 10.3390/nu2010075. Epub 2010 Jan 25.