Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi, India.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(11):1701-12. doi: 10.1080/10934529.2012.687294.
Amphiphilic copolymers, synthesized from poly(ethylene glycols) and various aliphatic and aromatic diacids, which self-assemble into nanomicellar aggregates in aqueous media, were used to develop controlled release (CR) formulations of thiamethoxam (3-(2-chloro-1,3-thiazol-5-ylmethyl)-5-methyl-1,3,5-oxadiazinan-4-ylidene(nitro)amine) using encapsulation technique Formulations were characterised by Infrared (IR) spectroscopy, Dynamic Light Scattering (DLS) and Transmission Electron Microscope (TEM). Encapsulation efficiency, loading capacity and stability after accelerated storage test of the developed formulations were checked. The kinetics of thiamethoxam, released in sandy loam soil from the different formulations was studied. Release from the commercial formulation was faster than the CR formulations. The time taken for release of 50 % of thiamethoxam ranged from 3.56 to 6.07 days for the CR formulations. Although the diffusion exponent (n value) of thiamethoxam in soil ranged from 0.532 to 0.881 in the tested formulations showing non-Fickian transport. These CR formulations may be used in safer, effective and economic crop protection.
两亲性嵌段共聚物由聚乙二醇和各种脂肪族和芳香族二羧酸合成，在水介质中自组装成纳米胶束聚集体，用于使用包封技术开发噻虫嗪（3-（2-氯-1,3-噻唑-5-基甲基）-5-甲基-1,3,5-恶二嗪-4-亚基（硝基）胺）的控释（CR）制剂。制剂通过红外（IR）光谱、动态光散射（DLS）和透射电子显微镜（TEM）进行表征。检查了开发制剂的包封效率、载药量和加速储存试验后的稳定性。研究了不同制剂在砂壤土中噻虫嗪的释放动力学。商业制剂的释放速度快于控释制剂。控释制剂中噻虫嗪释放 50%的时间范围为 3.56 至 6.07 天。尽管噻虫嗪在土壤中的扩散指数（n 值）在测试制剂中从 0.532 到 0.881 不等，表明非菲克扩散。这些控释制剂可用于更安全、有效和经济的作物保护。
