Elabasy Asem, Shoaib Ali, Waqas Muhammad, Shi Zuhua, Jiang Mingxing
Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.
Department of Pesticides, Plant Protection Research Institute, Agricultural Research Center, Cairo 11341, Egypt.
Nanomaterials (Basel). 2020 Apr 20;10(4):788. doi: 10.3390/nano10040788.
Using smart nanopesticide formulations based on nanomaterials can offer promising potential applications for decreasing pesticide residues and their effects on human health and the environment. In this study, a novel nanoformulation (NF) of thiamethoxam (TMX) was fabricated using the solvent evaporation method through loading TMX on cellulose nanocrystals (CNCs) as the carrier. The synthesized TMX-CNCs was investigated through different techniques, such as Fourier transform infrared spectrometer (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), and thermogravimetric analysis (TGA). The results revealed that the loading efficiency and entrapment efficiency were 18.7% and 83.7 ± 1.8% for TMX, respectively. The prepared nanoformulation (TMX-CNCs) had a width of 7-14 nm and a length of 85-214 nm with a zeta potential of -23.6 ± 0.3 mV. The drug release behavior study exhibited that the release of TMX from TMX-loaded CNCs was good and sustained. Furthermore, bioassay results showed that the insecticidal activity of TMX-CNCs against was significantly superior to that of the technical and commercial formulation, as indicated by the lower LC value. The results indicate that the TMX nanoformulation has great potential for application in agriculture for pest control.
使用基于纳米材料的智能纳米农药制剂可为减少农药残留及其对人类健康和环境的影响提供有前景的潜在应用。在本研究中，通过将噻虫嗪（TMX）负载在纤维素纳米晶体（CNCs）作为载体上，采用溶剂蒸发法制备了一种新型的噻虫嗪纳米制剂（NF）。通过傅里叶变换红外光谱仪（FT-IR）、X射线衍射（XRD）、透射电子显微镜（TEM）、动态光散射（DLS）和热重分析（TGA）等不同技术对合成的TMX-CNCs进行了研究。结果表明，TMX的负载效率和包封效率分别为18.7%和83.7±1.8%。制备的纳米制剂（TMX-CNCs）宽度为7-14nm，长度为85-214nm，zeta电位为-23.6±0.3mV。药物释放行为研究表明，负载TMX的CNCs中TMX的释放良好且持续。此外，生物测定结果表明，TMX-CNCs对[具体害虫未提及]的杀虫活性明显优于原药和商业制剂，较低的LC值表明了这一点。结果表明，TMX纳米制剂在农业害虫防治中具有巨大的应用潜力。
