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人源Grb7-SH2结构域与erbB2受体肽pY1139复合物的水相精制溶液结构

Water-refined solution structure of the human Grb7-SH2 domain in complex with the erbB2 receptor peptide pY1139.

作者信息

Pias Sally C, Johnson Dennis L, Smith David E, Lyons Barbara A

机构信息

Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003-8001, USA.

出版信息

Protein Pept Lett. 2012 Aug;19(8):832-8. doi: 10.2174/092986612801619543.

DOI:10.2174/092986612801619543
PMID:22702899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3758482/
Abstract

We report a refinement in implicit water of the previously published solution structure of the Grb7-SH2 domain bound to the erbB2 receptor peptide pY1139. Structure quality measures indicate substantial improvement, with residues in the most favored regions of the Ramachandran plot increasing by 14 % and with WHAT IF statistics (Vriend, G. J. Mol. Graph., 1990, 8(1), 52-56) falling closer to expected values for well-refined structures.

摘要

我们报告了对先前发表的与erbB2受体肽pY1139结合的Grb7-SH2结构域溶液结构中隐式水的优化。结构质量指标显示有显著改善，拉氏图最有利区域的残基增加了14%，并且WHAT IF统计值（Vriend, G. J. Mol. Graph., 1990, 8(1), 52 - 56）更接近结构优化良好的预期值。

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J Mol Biol. 2011 Sep 23;412(3):397-411. doi: 10.1016/j.jmb.2011.07.030. Epub 2011 Jul 23.
2
Scrutinizing molecular mechanics force fields on the submicrosecond timescale with NMR data.用 NMR 数据在亚微秒时间尺度上仔细研究分子力学力场。
Biophys J. 2010 Jul 21;99(2):647-55. doi: 10.1016/j.bpj.2010.04.062.
3
Structural refinement of insecticidal plant proteinase inhibitors from Nicotiana alata.
Protein Pept Lett. 2008;15(9):903-9. doi: 10.2174/092986608785849326.
4
The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner.细胞迁移蛋白Grb7以Grb7磷酸化依赖的方式与转录调节因子FHL2结合。
J Mol Recognit. 2009 Jan-Feb;22(1):9-17. doi: 10.1002/jmr.916.
5
BioMagResBank.生物磁共振数据库
Nucleic Acids Res. 2008 Jan;36(Database issue):D402-8. doi: 10.1093/nar/gkm957. Epub 2007 Nov 4.
6
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7
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8
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Proteins. 2006 Nov 15;65(3):712-25. doi: 10.1002/prot.21123.
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Bioinformatics. 2006 Jan 15;22(2):195-201. doi: 10.1093/bioinformatics/bti770. Epub 2005 Nov 13.