醛通过与手性双氮钳配体可逆 C-C 偶联结合，实现 PN P-钌催化剂催化的醇脱氢反应。
Aldehyde binding through reversible C-C coupling with the pincer ligand upon alcohol dehydrogenation by a PNP-ruthenium catalyst.
机构信息
Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76000, Israel.
出版信息
J Am Chem Soc. 2012 Jun 27;134(25):10325-8. doi: 10.1021/ja303121v. Epub 2012 Jun 15.
PMID:22703115
Abstract
Primary alcohol dehydrogenation by a PNP-Ru(II) catalyst was probed by low-temperature NMR experiments. Facile dehydrogenation occurred at -30 °C, but the resulting aldehydes were not found in solution, as they were trapped by the catalyst through a new mode of metal-ligand cooperation involving Ru-O coordination and an unusual, highly reversible C-C coupling with the PNP pincer ligand.
摘要
通过低温 NMR 实验研究了 PNP-Ru(II) 催化剂引发的伯醇脱氢反应。在-30°C 下即可实现醇的脱氢反应，但生成的醛并未在溶液中检出，因为它们通过涉及 Ru-O 配位和 PNP 钳形配体的一种不寻常的、高度可逆的 C-C 偶联的全新的金属-配体协同作用方式被催化剂捕获。
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