Department of Neurology, Universitätsmedizin Charité, Berlin, Germany.
Int J Neurosci. 2012 Nov;122(11):630-6. doi: 10.3109/00207454.2012.702819. Epub 2012 Jul 24.
Cognitive deficits are often observed during the acute stage of encephalitis. It is presumed, that they persist and influence the long-term outcome, but data are very limited. Forty-seven patients with a definite or highly probable diagnosis of acute encephalitis were identified through retrospective analysis and prospectively followed up 6-84 months after the acute illness. P3 was carried out by oddball auditory paradigm, and P3 latency was measured as a marker of cognitive impairment. Healthy people, who matched the patients in age, were used as controls (n = 39). Statistical group analysis revealed no significant difference of the P3 latency between the patient and the control group. However a subgroup analysis showed significant longer P3 latencies in patients with a more unfavorable functional outcome at the time of follow-up. Patients with Herpes simplex virus (HSV) encephalitis had also more often abnormal P3 values compared to other etiologic subgroups, potentially indicating a higher percentage of patients with unfavorable cognitive outcome in this subgroup.
认知缺陷在脑炎的急性期经常观察到。据推测，它们会持续存在并影响长期预后，但数据非常有限。通过回顾性分析确定了 47 名明确或高度可能诊断为急性脑炎的患者，并在急性疾病后 6-84 个月进行前瞻性随访。通过Oddball 听觉范式进行 P3 测试，并测量 P3 潜伏期作为认知障碍的标志物。匹配患者年龄的健康人作为对照组（n=39）。统计组分析显示，患者组和对照组之间的 P3 潜伏期没有显著差异。然而，亚组分析显示，在随访时功能预后更不利的患者中，P3 潜伏期显著延长。与其他病因亚组相比，单纯疱疹病毒（HSV）脑炎患者的 P3 值也更常异常，这可能表明该亚组中认知预后不良的患者比例更高。
