Cui Yong, Liu Fan, Zhang Xin-yuan, Tang Peng, Liu Peng, Zhang Biao, Liu Ji-hui
Department of Clinical Forensic Medicine, School of Forensic Medicine, China Medical University, Shenyang 110001, China.
Fa Yi Xue Za Zhi. 2009 Feb;25(1):19-23.
To assess the cognitive dysfunction in patients with the traumatic brain injury (TBI) by auditory P300.
Auditory P300 was recorded in the normal subjects and patients with TBI at the active (foot pedal) and passive task.
In healthy persons, N2 and P3 in active task state showed higher amplitude than that in passive task state, and no significant prolongation of the latency. The amplitude of N1 and P2 at Cz was higher than that at Pz. In passive task state, N2 and P3 showed higher amplitude and longer latency in the patients than that in the healthy persons. N2 and P3 of the patients in the active task showed higher amplitude and longer latency than that in the passive task. Obvious change of P3 latency was observed in the patients with attention disorder.
The type of task mainly affect the amplitude of N2 and P3. The latency of N2 and P3 in passive task can be used as an indication for evaluating cognitive function in patients with diffuse brain injury.
通过听觉P300评估创伤性脑损伤（TBI）患者的认知功能障碍。
在正常受试者和TBI患者中记录主动（脚踏）和被动任务下的听觉P300。
在健康人中，主动任务状态下的N2和P3波幅高于被动任务状态，潜伏期无明显延长。Cz点的N1和P2波幅高于Pz点。在被动任务状态下，患者的N2和P3波幅高于健康人，潜伏期更长。主动任务下患者的N2和P3波幅高于被动任务，潜伏期更长。注意力障碍患者的P3潜伏期有明显变化。
任务类型主要影响N2和P3的波幅。被动任务下N2和P3的潜伏期可作为评估弥漫性脑损伤患者认知功能的指标。
