Poole D C, Mathieu-Costello O
Department of Medicine, University of California, San Diego, La Jolla 92093-0623.
Respir Physiol. 1990 Oct;82(1):1-10. doi: 10.1016/0034-5687(90)90019-u.
The plasticity of capillary orientation in response to combined hypoxic hypoxia and high activity levels was investigated in anterior tibialis muscle of Japanese waltzing mice (Mus wagneri rotans). Following 2 weeks of normobaric, normothermic hypoxia (PIO2 congruent to 87 Torr), muscles were perfusion-fixed in situ with glutaraldehyde and analyzed morphometrically. Muscles from hypoxic waltzers, HW, were compared with those from normoxic waltzers, NW, and normoxic control mice, N. At sarcomere lengths from 2.84 to 1.69 microns, tortuosity and branching increased capillary length 3 to 38%. When capillary orientation was related to sarcomere length, muscles from HW were not different from NW or N. At group-averaged sarcomere lengths of 2.22 microns (HW), 2.33 microns (NW) and 2.35 microns (N), tortuosity and branching contributed 16,20 and 18% respectively, to capillary length. We conclude that high activity levels under normoxic or hypoxic conditions in Japanese waltzing mice do not augment muscle capillary length by means of increased capillary tortuosity and/or branching.
在日本华尔兹小鼠（Mus wagneri rotans）的胫前肌中，研究了毛细血管方向对低氧和高活动水平联合作用的可塑性。在常压、常温低氧（PIO2相当于87 Torr）环境下饲养2周后，将肌肉原位用戊二醛灌注固定，并进行形态计量分析。将低氧华尔兹小鼠（HW）的肌肉与常氧华尔兹小鼠（NW）和常氧对照小鼠（N）的肌肉进行比较。在肌节长度从2.84微米到1.69微米范围内，曲折度和分支使毛细血管长度增加了3%至38%。当毛细血管方向与肌节长度相关时，HW小鼠的肌肉与NW或N小鼠的肌肉没有差异。在组平均肌节长度分别为2.22微米（HW）、2.33微米（NW）和2.35微米（N）时，曲折度和分支分别使毛细血管长度增加了16%、20%和18%。我们得出结论，在日本华尔兹小鼠的常氧或低氧条件下，高活动水平并不会通过增加毛细血管曲折度和/或分支来增加肌肉毛细血管长度。
