Department of Pediatrics and Neonatology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
Pediatr Neurol. 2012 Jul;47(1):35-9. doi: 10.1016/j.pediatrneurol.2012.04.015.
Periventricular leukomalacia is recognized as the leading cause of cerebral palsy in preterm infants. To clarify the prevalence of periventricular leukomalacia and cerebral palsy in Japan, a nationwide survey was performed. The prevalence of periventricular leukomalacia in the group of surviving preterm infants of gestational ages less than 33 weeks born in 2007 was 2.7% (78/2883) on ultrasound diagnosis, and 3.3% (92/2824) on magnetic resonance imaging. The prevalence of cerebral palsy was 4.3% (125/2883) on clinical diagnosis. In our previous study, the prevalences of periventricular leukomalacia in 1990-1991, 1993-1994, 1996, and 1999 were 4.8%, 4.9%, 4.9%, and 5.3% on ultrasound, and 7.9%, 7.7%, 6.9%, and 7.3% on magnetic resonance imaging, respectively. The prevalence of periventricular leukomalacia has decreased significantly in Japan.
脑室周围白质软化症被认为是早产儿脑瘫的主要原因。为了阐明日本脑室周围白质软化症和脑瘫的流行情况，进行了一项全国性调查。2007 年，在超声诊断下，胎龄小于 33 周的存活早产儿中脑室周围白质软化症的患病率为 2.7%（2883 例中的 78 例），磁共振成像下为 3.3%（2824 例中的 92 例）。临床诊断脑瘫的患病率为 4.3%（2883 例中的 125 例）。在我们之前的研究中，1990-1991 年、1993-1994 年、1996 年和 1999 年，超声下脑室周围白质软化症的患病率分别为 4.8%、4.9%、4.9%和 5.3%，磁共振成像下分别为 7.9%、7.7%、6.9%和 7.3%。日本脑室周围白质软化症的患病率显著下降。
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