Section of Pediatric Neurology, Department of Neurology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Pediatr Neurol. 2012 Jul;47(1):65-7. doi: 10.1016/j.pediatrneurol.2012.04.002.
Levetiracetam is a commonly prescribed antiepileptic drug, and is generally well tolerated, but can eventually cause behavioral disturbances. These disturbances seem more frequent in children and in patients with a previous psychiatric history. We report on reversible autistic regression induced by levetiracetam in a 6-year-old girl with spastic cerebral palsy, mild cognitive deficiency, and focal epilepsy. She was diagnosed with pervasive developmental disorder, and demonstrated mild to moderate impairment in pragmatic language and interactions with peers. After the introduction of levetiracetam, she developed stereotypies, and her social and communicative skills deteriorated severely. She also exhibited mood lability. When the medication was discontinued, a dramatic response occurred, with a complete resolution of new abnormal findings. Levetiracetam can provoke unusual behavioral adverse effects in certain patients who are biologically more vulnerable.
左乙拉西坦是一种常用的抗癫痫药物，通常具有良好的耐受性，但最终可能会引起行为障碍。这些障碍在儿童和有既往精神病史的患者中似乎更为常见。我们报告了一例由左乙拉西坦引起的、6 岁痉挛性脑瘫女孩的可逆性自闭症退行，该女孩伴有轻度认知障碍和局灶性癫痫。她被诊断为广泛性发育障碍，表现为轻度至中度语用和同伴互动障碍。左乙拉西坦引入后，她出现刻板行为，社会和沟通技能严重恶化。她还表现出情绪不稳定。当药物停止使用时，出现了显著的反应，新的异常发现完全消失。左乙拉西坦可能会在某些生物学上更脆弱的患者中引发异常的行为不良反应。
