Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 619 19th St. South, 176 F, Suite 10382, Birmingham, Alabama 35249, USA.
J Urol. 2012 Aug;188(2):485-9. doi: 10.1016/j.juro.2012.04.010. Epub 2012 Jun 15.
We examined preoperative and postoperative patient related factors associated with continence status up to 7 years after surgery for stress urinary incontinence.
Women randomized to Burch colposuspension or fascial sling surgery and assessed for the primary outcome of urinary continence 2 years after surgery were eligible to enroll in a prospective observational study. Survival analysis was used to investigate baseline and postoperative factors in the subsequent risk of stress urinary incontinence, defined as self-report of stress urinary incontinence symptoms, incontinence episodes on a 3-day diary or surgical re-treatment.
Of the women who participated in the randomized trial 74% (482 of 655) were enrolled in the followup study. Urinary continence rates decreased during a period of 2 to 7 years postoperatively from 42% to 13% in the Burch group and from 52% to 27% in the sling group, respectively. Among the baseline factors included in the first multivariable model age (p = 0.03), prior stress urinary incontinence surgery (p = 0.02), menopausal status (0.005), urge index (0.006), assigned surgery (p = 0.01) and recruiting site (p = 0.02) were independently associated with increased risk of incontinence. In the final multivariable model including baseline and postoperative factors, Burch surgery (p = 0.01), baseline variables of prior urinary incontinence surgery (p = 0.04), menopausal status (p = 0.03) and postoperative urge index (p <0.001) were each significantly associated with a greater risk of recurrent urinary incontinence.
Preoperative and postoperative urgency incontinence symptoms, Burch urethropexy, prior stress urinary incontinence surgery and menopausal status were negatively associated with long-term continence rates. More effective treatment of urgency urinary incontinence in patients who undergo stress urinary incontinence surgery may improve long-term overall continence status.
我们研究了术前和术后与压力性尿失禁患者相关的因素,这些因素与术后 7 年内的尿控状态有关。
接受 Burch 耻骨后悬吊术或筋膜吊带术治疗并在术后 2 年评估尿控主要结局的女性有资格参加前瞻性观察研究。生存分析用于研究基线和术后因素与随后压力性尿失禁的风险,定义为自我报告的压力性尿失禁症状、3 天日记中的尿失禁发作或手术再治疗。
在参加随机试验的女性中,74%(482/655)参加了随访研究。在术后 2 至 7 年期间,尿控率从 Burch 组的 42%降至 13%,从吊带组的 52%降至 27%。纳入第一多变量模型的基线因素包括年龄(p=0.03)、既往压力性尿失禁手术(p=0.02)、绝经状态(0.005)、急迫指数(0.006)、分配手术(p=0.01)和招募地点(p=0.02)与失禁风险增加独立相关。在包括基线和术后因素的最终多变量模型中,Burch 手术(p=0.01)、基线变量的既往尿失禁手术(p=0.04)、绝经状态(p=0.03)和术后急迫指数(p<0.001)均与复发性尿失禁的风险显著相关。
术前和术后急迫性尿失禁症状、Burch 尿道悬带术、既往压力性尿失禁手术和绝经状态与长期尿控率呈负相关。在接受压力性尿失禁手术的患者中更有效地治疗急迫性尿失禁可能会改善长期整体尿控状态。