Rahman M, Huq F, Sack D A, Butler T, Azad A K, Alam A, Nahar N, Islam M
International Centre for Diarrhoeal Disease Research, Mohakhali, Dhaka, Bangladesh.
Rev Infect Dis. 1990 Nov-Dec;12 Suppl 8:S899-906. doi: 10.1093/clinids/12.supplement_8.s899.
This study focused on 401 children less than 5 years old who were hospitalized with acute lower respiratory tract infection (ALRI) and diarrhea in Dhaka, Bangladesh, and who were investigated for the presence of both bacterial and viral respiratory tract pathogens as well as for selected diarrheal pathogens. The most common manifestations of ALRI were pneumonia (374 cases), bronchiolitis (12 cases), and tracheobronchitis (11 cases). The majority (77%) of the illnesses were in children less than 2 years of age, and 88% of the children were malnourished. A respiratory tract pathogen was identified in 30% of the patients, and a diarrheal pathogen was identified in 34%. The overall case-fatality rate in children with ALRI and diarrhea was 8%. The case-fatality rate was 14% in children with bacterial pneumonia and diarrhea, 3% in those with viral pneumonia and diarrhea, and 14% in malnourished children with shigellosis and ALRI. The most common respiratory tract pathogens were respiratory syncytial virus, Streptococcus pneumoniae, influenza viruses, and Haemophilus influenzae type b.
本研究聚焦于孟加拉国达卡401名5岁以下因急性下呼吸道感染（ALRI）和腹泻住院的儿童，对其进行了细菌和病毒呼吸道病原体以及特定腹泻病原体的检测。ALRI最常见的表现为肺炎（374例）、细支气管炎（12例）和气管支气管炎（11例）。大多数（77%）患病儿童年龄小于2岁，88%的儿童营养不良。30%的患者检测出呼吸道病原体，34%检测出腹泻病原体。ALRI和腹泻患儿的总体病死率为8%。细菌性肺炎和腹泻患儿的病死率为14%，病毒性肺炎和腹泻患儿为3%，营养不良且患志贺菌病和ALRI的患儿为14%。最常见的呼吸道病原体是呼吸道合胞病毒、肺炎链球菌、流感病毒和b型流感嗜血杆菌。
