Perciun R, Mincu I
Clinic of Diabetes, Nutrition and Metabolic Diseases, Bucharest, Romania.
Med Interne. 1990 Apr-Jun;28(2):91-101.
The ever increasing incidence of diabetes mellitus has stimulated the immunologic investigations concerned with the role of heredity and the toleration rate of transplants of pancreas organ or islet structures. Concomitant or subsequent trials have attempted to define or avoid the apparently diabetogenic factors. With respect to the effectiveness of diabetes therapy, one cannot deny the contrast between the practical and the theoretical aspects. Besides the technical difficulties, the pancreas organ or islet cell transplants are confronted with the still limited possibilities of immunosuppression. The recent concept of a bioartificial organ is an attempt to avoid such disadvantages. The present paper is a review of the main achievements of the experimental and the clinical trials in the above-mentioned directions of research work.
糖尿病发病率的不断上升激发了免疫学研究，这些研究关注遗传的作用以及胰腺器官或胰岛结构移植的耐受率。随之而来或后续进行的试验试图确定或避免明显的致糖尿病因素。关于糖尿病治疗的有效性，人们无法否认实际方面与理论方面之间的差异。除了技术难题外，胰腺器官或胰岛细胞移植还面临免疫抑制可能性仍然有限的问题。生物人工器官的最新概念是试图避免此类弊端。本文综述了上述研究方向的实验和临床试验的主要成果。
