Barker C F, Naji A, Perloff L J, Dafoe D C, Bartlett S
Surgery. 1982 Aug;92(2):133-7.
The clinical results of vascularized pancreas transplants have improved somewhat during the last 5 years, the but technical problems of handling the pancreatic duct remain difficult. Clinical isolated islet allografts have rarely if ever succeeded. Rejection appears to be a more severe problem in pancreas or islet transplants than in other pancreas transplants. Nevertheless, if nonendocrine cells can be completely removed, transplanted beta-cells might have prolonged survival, since they probably lack Ia antigens that may be necessary to evoke an immune response. An additional biologic problem is the possible destruction (independent of rejection) of transplanted islet cells by autoimmune insulitis. This has been found to occur in spontaneously diabetic rats who received transplanted islets. Study of this animal model may provide important clues to the etiology and treatment or prevention of diabetes.
在过去5年里，血管化胰腺移植的临床结果有所改善，但处理胰管的技术问题仍然棘手。临床孤立胰岛同种异体移植极少成功，即便有过成功案例也是凤毛麟角。排斥反应在胰腺或胰岛移植中似乎比在其他器官移植中更为严重。然而，如果能完全去除非内分泌细胞，移植的β细胞或许能延长存活时间，因为它们可能缺乏引发免疫反应所需的Ia抗原。另一个生物学问题是，移植的胰岛细胞可能会因自身免疫性胰岛炎而遭到破坏（与排斥反应无关）。这一现象已在接受胰岛移植的自发性糖尿病大鼠身上被发现。对这种动物模型的研究可能会为糖尿病的病因、治疗或预防提供重要线索。
