Mihăilescu P, Calciu B, Ionescu J
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1979 Apr-Jun;28(2):85-93.
The development of several cases of miliary tuberculosis in infants aged 3--4 months, born in the same maternity led to an epidemiological investigation. On this occasion it was discovered that one of the patients that had been discharged immediately after delivery had pulmonary granulia a monthlater. The immature newborn was left in the maternity and died after one month with a diagnosis of "pulmonary microabscesses". The histopathologic examination of the lungs showed the presence of necrotic foci without any cellular reaction. Five months after the death of the infant a new examination of a pulmonary fragment was performed and Ziehl-Neelsen staining evidenced a large number of acido-resistant bacilli filling the lung alveoles. It was shown in this way that the infant with tuberculosis was the primary source of infection. All the 8 children that had developed the disease had been hospitalized in the same ward with the sick child. The transmission of the bacilli was done indirectly, through the feeding tubes that had not been sufficiently serilised, and the penetration ronte was the digestive tract. In two cases an otic primary focus was discovered and in one case an intestinal one was found on necropsy.
在同一产科出生的3至4个月大婴儿中出现了几例粟粒性肺结核病例,这引发了一项流行病学调查。在此期间发现,其中一名产后立即出院的患者一个月后出现了肺部肉芽肿。这名未成熟的新生儿留在产科,一个月后死亡,诊断为“肺微脓肿”。肺部组织病理学检查显示存在坏死灶,无任何细胞反应。婴儿死亡五个月后,对肺部碎片进行了重新检查,齐尔-尼尔森染色显示大量抗酸杆菌充满肺泡。由此表明,患结核病的婴儿是主要传染源。所有8名患病儿童都与患病儿童住在同一病房。杆菌通过未充分消毒的喂食管间接传播,传播途径是消化道。尸检发现2例有耳部原发灶,1例有肠道原发灶。