Department of Neurological Surgery and Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Department of Neurological Surgery and Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Cell Stem Cell. 2012 Jun 14;10(6):698-708. doi: 10.1016/j.stem.2012.05.012.
Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranular zone (SGZ), with signaling pathways that control the behavior of NSCs. NSCs in the adult brain stretch into physiologically distinct compartments of their niche. We propose how adult NSCs' morphology may allow these cells to integrate multiple signaling pathways arising from unique locations of their niche.
近年来神经干细胞（NSC）领域的重大发展为 NSC 生态位的本质提供了新的见解。在这个观点中，我们将最近关于成年大脑中两个主要神经发生生态位——脑室下区（V-SVZ）和颗粒下区（SGZ）的组织的解剖学数据与控制 NSCs 行为的信号通路整合在一起。成年大脑中的 NSCs 延伸到其生态位的生理上不同的隔室中。我们提出了成年 NSCs 的形态如何使这些细胞整合来自其生态位独特位置的多种信号通路。
