Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, PR China.
Int J Oral Maxillofac Surg. 2012 Nov;41(11):1330-7. doi: 10.1016/j.ijom.2012.05.014. Epub 2012 Jun 14.
The purpose of this study was to evaluate the properties of a novel inorganic xenogenic bone substitute, calcinated antler cancellous bone (CACB). Physicochemical properties of CACB including surface morphology, phase composition, chemical bond structure, Ca/P ratio and porosity were characterized by scanning electron microscopy, X-ray diffraction spectroscopy, Fourier-transform infrared spectroscopy, inductively coupled plasma-atomic emission spectroscopy and nitrogen adsorption analysis, and were found to closely resemble calcinated human cancellous bone. The bone defect repair efficacy of CACB was evaluated in comparison with commercially available bone substitutes (Bio-Oss(®)) within rabbit mandible defects. The gross observation, micro-CT and histology analysis data demonstrated that CACB was efficacious for bone regeneration, and was comparable with Bio-Oss(®) bone substitute in inducing neovascularization and osteogenesis within the mandible defects. CACB can therefore serve as a safe, renewable, and sustainable source of bone graft material, but without the ethical issues pertaining to animal welfare.
本研究旨在评估一种新型无机异种骨替代物——煅制鹿角松质骨（CACB）的特性。通过扫描电子显微镜、X 射线衍射光谱、傅里叶变换红外光谱、电感耦合等离子体原子发射光谱和氮气吸附分析，对 CACB 的表面形态、相组成、化学键结构、Ca/P 比和孔隙率等理化性质进行了表征，结果表明其与煅制人松质骨非常相似。通过比较 CACB 与市售骨替代物（Bio-Oss(®)）在兔下颌骨缺损中的修复效果，评估了 CACB 的骨缺损修复效果。大体观察、微 CT 和组织学分析数据表明，CACB 具有促进骨再生的功效，在诱导下颌骨缺损内新血管生成和成骨方面与 Bio-Oss(®)骨替代物相当。因此，CACB 可以作为一种安全、可再生和可持续的骨移植材料，但不存在与动物福利相关的伦理问题。
