Chronic Illness Research Team, University of East London, London, UK.
Otol Neurotol. 2012 Jul;33(5):816-23. doi: 10.1097/MAO.0b013e3182536ac6.
The goal of this study was to assess the impact of dizziness handicap, illness intrusiveness (in relation to vertigo, tinnitus, and hearing problems), and illness uncertainty on depression in people with the symptoms of Ménière's disease.
Ménière's disease is a progressive disease of the inner ear, the symptoms of which are vertigo, tinnitus, hearing loss, and aural fullness. Although pharmacologic treatments may reduce acute vertigo spells and dizziness, they rarely disappear entirely. Previous research shows that Ménière's disease is unpredictable and has a negative impact on patients' quality of life.
Questionnaires measuring Dizziness Handicap, Illness Intrusiveness, Illness Uncertainty, and Depression were completed by 74 people with self-reported symptoms of Ménière's disease. Bivariate correlations, repeated-measures analysis of variance, and multiple regression analyses were used to assess the contribution of dizziness handicap, illness intrusiveness, and illness uncertainty to depression.
Vertigo was more intrusive than tinnitus, hearing problems, and most other comparator illnesses. The intrusiveness of the symptoms of Ménière's disease accounted for 32% of the variance in depression scores, which were high; illness uncertainty did not account for additional variance. Dizziness handicap accounted for 31% of the variation in depression. Although the symptoms of Ménière's disease may not be alleviated by psychological methods, programs that target cognitions in relation to the embarrassment in front of others, and the feeling of being handicapped, may lessen the psychosocial impact of the symptoms of Ménière's disease, which may reduce some of the depression felt in this group.
本研究的目的是评估头晕障碍、疾病侵扰（与眩晕、耳鸣和听力问题有关）和疾病不确定性对梅尼埃病症状患者抑郁的影响。
梅尼埃病是一种内耳进行性疾病，其症状为眩晕、耳鸣、听力损失和耳闷。虽然药物治疗可能会减少急性眩晕发作和头晕，但它们很少完全消失。先前的研究表明，梅尼埃病是不可预测的，对患者的生活质量有负面影响。
通过问卷调查，评估 74 名自我报告有梅尼埃病症状的患者的头晕障碍、疾病侵扰、疾病不确定性和抑郁程度。采用双变量相关分析、重复测量方差分析和多元回归分析来评估头晕障碍、疾病侵扰和疾病不确定性对抑郁的影响。
与耳鸣、听力问题和大多数其他比较性疾病相比，眩晕更具侵扰性。梅尼埃病症状的侵扰性解释了抑郁评分 32%的差异，差异程度较高；疾病不确定性没有额外的解释差异。头晕障碍占抑郁变化的 31%。尽管梅尼埃病的症状可能无法通过心理方法缓解，但针对因他人面前的尴尬和残疾感而产生的认知的干预计划可能会减轻梅尼埃病症状对社会心理的影响，从而减轻该群体中感受到的部分抑郁。
