一种用于DNA酶促超螺旋的符号反转机制。
A sign inversion mechanism for enzymatic supercoiling of DNA.
作者信息
Brown P O, Cozzarelli N R
出版信息
Science. 1979 Nov 30;206(4422):1081-3. doi: 10.1126/science.227059.
PMID:227059
Abstract
Both the introduction and the removal of supertwists by DNA gyrase change the linking number of DNA in steps of two. This surprising finding provides strong evidence that gyrase acts by a mechanism, called sign inversion, whereby a positive supercoil is directly inverted into a negative one via a transient double-strand break.
摘要
DNA促旋酶引入和去除超螺旋都会使DNA的连环数呈两个单位的步长变化。这一惊人发现有力地证明，促旋酶通过一种称为符号反转的机制起作用，即通过一个瞬时双链断裂，将一个正超螺旋直接转化为一个负超螺旋。
Zotero 插件