Bondarenko T I, Krichevskaia A A, Sheĭkina I V, Kiriukhina E V
Ukr Biokhim Zh (1978). 1990 Sep-Oct;62(5):34-8.
Adrenalin content in the brain, liver and adrenal glands under the effect of cold stress grows by 314, 500 and 56% as compared to the control. A single administration of the delta-sleep inducing peptide (DSIP) in a dose of 12 microgram/100 g to intact animals makes the adrenalin content in the brain higher 1, 3, 6 and 24h after administration; two and three days later the adrenalin content in the brain does not change. The amount of adrenalin in the liver of the same animals increases 1, 3, 6 h and 1, 2, 3 days after DSIP administration. Intraperitoneal administration of DSIP induces an increase of the adrenalin level in the adrenal glands of rats an hour and a day after administration. Two days later the level of adrenaline decreases by 41%; 3, 6 h and 3 days after DSIP administration the content of adrenaline remains unchanged. As a result of the DSIP administration in a dose of 12 micrograms/100 g to the animals in the state of cold stress, the content of adrenalin increases in the rat brain by 129, in the liver--by 300, adrenal glands--by 44% as compared with the control.
与对照组相比，在冷应激作用下，大脑、肝脏和肾上腺中的肾上腺素含量分别增加314%、500%和56%。给正常动物单次注射剂量为12微克/100克的δ-睡眠诱导肽（DSIP）后，给药后1、3、6和24小时大脑中的肾上腺素含量升高；两天和三天后大脑中的肾上腺素含量没有变化。相同动物肝脏中的肾上腺素含量在DSIP给药后1、3、6小时以及1、2、3天增加。腹腔注射DSIP可使大鼠肾上腺中的肾上腺素水平在给药后1小时和1天升高。两天后肾上腺素水平下降41%；DSIP给药后3、6小时和3天，肾上腺素含量保持不变。给处于冷应激状态的动物注射剂量为12微克/100克的DSIP后，与对照组相比，大鼠大脑中的肾上腺素含量增加129%，肝脏中增加300%，肾上腺中增加44%。
