Bondarenko T I, Miliutina N P, Shustanova T A, Mikhaleva I I
Rostov State University, Russia.
Ross Fiziol Zh Im I M Sechenova. 1999 Aug;85(8):1080-4.
I. p. administration of exogenous delta-sleep-inducing peptide (DSIP) decreased the amount of diene conjugates and Schiff bases in the liver and brain in rats. The xanthine oxidase activity, at that, did not change. Cold stress enhanced the xanthine oxidase activity well as the amount of diene conjugates and Schiff bases. Preliminary administration of the delta-sleep-inducing peptide to cold-exposed animals diminished the xanthine oxidase activity and lipid peroxidation in the liver and brain. Protective effects of the DSIP under stress is discussed.
腹腔注射外源性δ-睡眠诱导肽（DSIP）可减少大鼠肝脏和大脑中双烯共轭物和席夫碱的含量。此时，黄嘌呤氧化酶的活性并未改变。冷应激会增强黄嘌呤氧化酶的活性以及双烯共轭物和席夫碱的含量。预先给冷暴露动物注射δ-睡眠诱导肽可降低肝脏和大脑中的黄嘌呤氧化酶活性和脂质过氧化作用。文中讨论了DSIP在应激状态下的保护作用。
