Paris-Descartes University, Maternité Port Royal, Paris, France.
Clin Chem Lab Med. 2012 Apr 14;50(6):1015-9. doi: 10.1515/cclm-2011-1850.
The preterm premature rupture of membranes (PPROM) is a common condition in pregnant women and is associated with significant maternal and perinatal morbidity. Most of the time, the diagnosis is done during physical examination. However, in 10%-20% of equivocal cases, biological markers are needed to confirm the diagnosis, especially when leakage of fluid is low or intermittent. In these cases, a quick and reliable diagnosis is necessary for applying the appropriate measures to reduce perinatal complications. The prognosis in PPROM is linked to maternal inflammatory markers that might predict perinatal infection, and therefore be helpful to decide the timing of the delivery. Nevertheless, further research is needed to identify robust biological markers for the diagnosis of PPROM in equivocal cases and for the prognosis.
胎膜早破（PPROM）是孕妇中常见的情况，与显著的母婴围产期发病率相关。大多数情况下，通过体格检查即可做出诊断。然而，在 10%-20%的可疑病例中，需要生物学标志物来确诊，特别是在羊水漏出量低或间歇性时。在这些情况下，需要快速可靠的诊断来采取适当的措施减少围产期并发症。PPROM 的预后与母体炎症标志物相关，这些标志物可能预测围产期感染，因此有助于决定分娩时机。然而，仍需要进一步的研究来确定在可疑病例中诊断 PPROM 和预测预后的可靠生物学标志物。
