伊朗中部伊斯法罕的丁型肝炎病毒感染：慢性乙肝感染病例中的患病率及危险因素
Hepatitis D virus infection in Isfahan, central Iran: Prevalence and risk factors among chronic HBV infection cases.
作者信息
Ataei Behrooz, Yazdani Mohammad Reza, Kalantari Hamid, Yaran Majid, Nokhodian Zary, Javadi Abbas Ali, Babak Anahita, Adibi Peyman
机构信息
Isfahan Infectious Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran.
出版信息
Hepat Mon. 2011 Apr 1;11(4):269-72.
BACKGROUND
Hepatitis D virus (HDV) is dependent on hepatitis B virus (HBV) infection. Acute infection with HDV can occur simultaneously with acute HBV infection or be superimposed onto a chronic HBV infection.
OBJECTIVES
This study aimed to identify cases of HDV and determine its prevalence in patients with chronic HBV infection for the first time study in Isfahan, central Iran.
PATIENTS AND METHODS
In a cross-sectional study in 2009, 346 who had been diagnosed for at least 6 months with chronic HBV were enrolled consecutively. Anti-HDV was measured by ELISA in the serum of these patients.
RESULTS
The study included 245 males (70.8%) and 101 (29.2%) females with a mean age of 39 ± 12.4 years. Anti-HDV was present in 8 (3.5%) HBe antibody-positive patients (p = 0.36) and in 2 (2.3%) HBe antigen-positive cases (p = 0.68). No association was found between hepatitis D and probable risk factors.
CONCLUSIONS
This study demonstrates that the prevalence of HDV infection is higher in patients who are positive for HBeAb compared those who are HBeAg-positive. Therefore, most HDV antibody-positive cases in Isfahan are HBV/HDV superinfections but not coinfections.
背景
丁型肝炎病毒（HDV）依赖于乙型肝炎病毒（HBV）感染。HDV急性感染可与HBV急性感染同时发生，或叠加于慢性HBV感染之上。
目的
本研究旨在首次在伊朗中部伊斯法罕对慢性HBV感染患者中HDV病例进行识别并确定其患病率。
患者与方法
在一项2009年的横断面研究中，连续纳入了346名已被诊断为慢性HBV至少6个月的患者。采用酶联免疫吸附测定法（ELISA）检测这些患者血清中的抗HDV。
结果
该研究纳入了245名男性（70.8%）和101名女性（29.2%），平均年龄为39±12.4岁。8名（3.5%）HBe抗体阳性患者（p = 0.36）和2名（2.3%）HBe抗原阳性患者（p = 0.68）存在抗HDV。未发现丁型肝炎与可能的危险因素之间存在关联。
结论
本研究表明，HBeAb阳性患者中HDV感染的患病率高于HBeAg阳性患者。因此，伊斯法罕大多数抗HDV抗体阳性病例为HBV/HDV重叠感染而非合并感染。
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