Celen Mustafa K, Ayaz Celal, Hosoglu Salih, Geyik Mehmet F, Ulug Mehmet
Dicle Universitesi Hastanesi, Klinik Mikrobiyoloji ve Enfeksiyon Hastaliklari Anabilim Dali, 21280, Diyarbakir, Turkey.
Saudi Med J. 2006 May;27(5):617-20.
To obtain regional epidemiological data on hepatitis delta virus (HDV, a defective virus) infections, the incidence of anti-HDV positivity and the associated risk factors in asymptomatic hepatitis B virus surface antigen (HBsAg) carriers and in patients with chronic active hepatitis B.
The study took place at Dicle University Hospital (Diyarbakir, Southeast of Turkey) between January 2002 and July 2004. Anti-HDV screening was performed in asymptomatic hepatitis B carriers (N=889) and in patients with chronic active hepatitis B infection (N=120). We explored the association between anti-HDV positivity and asymptomatic hepatitis B carrier status, presence of active hepatitis B, age, gender, the durations of HBsAg positivity and hepatitis B e antigen (HBeAg) positivity.
In 6% of asymptomatic hepatitis B carriers (53/889) and in 27.5% of patients with chronic active hepatitis B (33/120) anti-HDV was positive. The incidence of anti-HDV positivity was significantly higher in patients with chronic active hepatitis B compared with asymptomatic carriers (p<0.001). A significant association between the duration of HBsAg carrier status (3.2 +/- 1.4 years) and anti-HDV positivity was also found (p<0.001). Age, gender, and HBeAg positivity were not significantly associated with anti-HDV positivity (p>0.05).
Anti-HDV positivity was significantly more common in patients with chronic hepatitis B compared with asymptomatic hepatitis B virus (HBV) carriers in a region with a high prevalence of HBV infection. We found a significant relationship between the duration of HBsAg carrier status and anti-HDV positively, however, age, gender, and presence of HBeAg were not significantly associated with the development of anti-HDV positivity.
获取关于丁型肝炎病毒（HDV，一种缺陷病毒）感染的区域流行病学数据、无症状乙肝表面抗原（HBsAg）携带者及慢性活动性乙型肝炎患者中抗-HDV阳性率及相关危险因素。
该研究于2002年1月至2004年7月在土耳其东南部迪亚巴克尔的迪克莱大学医院进行。对无症状乙肝携带者（N = 889例）和慢性活动性乙型肝炎感染患者（N = 120例）进行抗-HDV筛查。我们探讨了抗-HDV阳性与无症状乙肝携带者状态、活动性乙型肝炎、年龄、性别、HBsAg阳性持续时间及乙肝e抗原（HBeAg）阳性之间的关联。
6%的无症状乙肝携带者（53/889）和27.5%的慢性活动性乙型肝炎患者（33/120）抗-HDV呈阳性。与无症状携带者相比，慢性活动性乙型肝炎患者中抗-HDV阳性率显著更高（p < 0.001）。还发现HBsAg携带者状态持续时间（3.2 ± 1.4年）与抗-HDV阳性之间存在显著关联（p < 0.001）。年龄、性别和HBeAg阳性与抗-HDV阳性无显著关联（p > 0.05）。
在HBV感染高发地区，与无症状乙肝病毒（HBV）携带者相比，慢性乙型肝炎患者中抗-HDV阳性更为常见。我们发现HBsAg携带者状态持续时间与抗-HDV阳性之间存在显著关系，然而，年龄、性别及HBeAg的存在与抗-HDV阳性的发生无显著关联。
