Picard J, Breton M, Deudon E
Sem Hop. 1979;55(15-16):748-52.
Arteriosclerosis is the consequence of numerous factors which may be studied by inspecting; the composition of blood (cholesterol) and haemostasis, as well as, modifications in the composition and structure of aging arterial-wall tissue. Arterial-tunica cells synthesise in particular, elastin and proteoglycan (mucopolysaccharide-protein complexes) which account for the artery's mechanical and elastic properties. We have shown by biochemical separation and characterization that proteoglycan synthesis is considerably modified in aging arterial tissue. The metabolism of these macromolecules declines. Large aggregates of proteoglycan form. Alterations are observed in the distribution of the different protein-associated long chain polysaccharides, in fatty acids and in calcium bound to these proteoglycans favorising the formation of arteriosclerotic plaques. Studies on the aging of arterial cells in culture also demonstrate these same alterations in proteoglycans.
动脉硬化是众多因素的结果，这些因素可以通过检查血液成分（胆固醇）和止血情况以及衰老动脉壁组织的成分和结构变化来研究。动脉中膜细胞尤其会合成弹性蛋白和蛋白聚糖（粘多糖 - 蛋白质复合物），它们决定了动脉的机械和弹性特性。我们通过生化分离和特性分析表明，在衰老的动脉组织中蛋白聚糖合成有显著改变。这些大分子的代谢下降。蛋白聚糖形成大聚集体。在与蛋白质相关的不同长链多糖的分布、脂肪酸以及与这些蛋白聚糖结合的钙中观察到变化，这些变化有利于动脉粥样硬化斑块的形成。对培养的动脉细胞衰老的研究也证明了蛋白聚糖存在同样的变化。
