葛林素 1 的表达与胰腺神经内分泌肿瘤患者的血管生成增加和无进展生存期相关。
Expression of gremlin 1 correlates with increased angiogenesis and progression-free survival in patients with pancreatic neuroendocrine tumors.
机构信息
Institute of Clinical Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong St., Taipei, 112, Taiwan.
出版信息
J Gastroenterol. 2013 Jan;48(1):101-8. doi: 10.1007/s00535-012-0614-z. Epub 2012 Jun 16.
BACKGROUND
Gremlin 1 (GREM1) is a bone morphogenetic protein antagonist and a novel proangiogenic factor. Our aim was to evaluate the prognostic value of GREM1 expression and GREM1-related factors in tumor-associated angiogenesis in pancreatic neuroendocrine tumors (NETs).
METHODS
The immunohistochemical expression of GREM1 and microvessel density (MVD) were examined in 35 patients with pancreatic NETs and then compared with other clinicopathologic characteristics, including the World Health Organization classification.
RESULTS
The presence of expression of GREM1 (p = 0.016) and high MVD (p = 0.020) were significant and favorable prognostic factors. Moreover, GREM1 expression was significantly associated with high MVD (p = 0.011). MVD was significantly higher in well-differentiated NETs than in well-differentiated or poorly differentiated neuroendocrine carcinomas (p < 0.001).
CONCLUSIONS
GREM1 expression was correlated with tumor-associated angiogenesis and was found to be a novel prognostic marker in pancreatic NETS. Our data support a tumor suppressor role of GREM1 in pancreatic NETs.
背景
Gremlin 1（GREM1）是骨形态发生蛋白拮抗剂和一种新的促血管生成因子。我们的目的是评估 GREM1 表达及其相关因素在胰腺神经内分泌肿瘤（NETs）中肿瘤相关血管生成中的预后价值。
方法
对 35 例胰腺 NETs 患者进行 GREM1 免疫组织化学表达和微血管密度（MVD）检测，并与其他临床病理特征（包括世界卫生组织分类）进行比较。
结果
GREM1 表达阳性（p=0.016）和 MVD 高（p=0.020）是显著的有利预后因素。此外，GREM1 表达与 MVD 高显著相关（p=0.011）。与分化良好的神经内分泌癌相比，分化良好的 NETs 的 MVD 显著更高（p<0.001）。
结论
GREM1 表达与肿瘤相关血管生成相关，是胰腺 NETs 的一种新的预后标志物。我们的数据支持 GREM1 在胰腺 NETs 中作为肿瘤抑制因子的作用。
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