Shannon Chevis N, Acakpo-Satchivi Leslie, Kirby Russell S, Franklin Frank A, Wellons John C
Division of Neurosurgery, Section of Pediatric Neurosurgery, Children's Hospital of Alabama, University of Alabama, 400 Ambulatory Care Center, 1600 7th Ave South, Birmingham, AL 35233, USA.
Childs Nerv Syst. 2012 Dec;28(12):2093-9. doi: 10.1007/s00381-012-1830-9. Epub 2012 Jun 17.
Prior research has examined predictors of shunt failure in children with hydrocephalus and concluded that the majority of shunts do not survive long-term. However, risk factors such as etiology, birth weight, and gestational age may vary across institutions and populations. We sought to identify the social, clinical, and neonatal factors associated with initial ventriculoperitoneal (VP) shunt failure in the intraventricular hemorrhage (IVH) patient population and the patient population with an etiology other than IVH (non-IVH).
A retrospective review of patients, born during 2000-2005 diagnosed and treated for hydrocephalus at Children's of Alabama was conducted. Survival analysis identified factors associated with time to shunt failure.
Analyses were done separately for the IVH and non-IVH cohorts. Age and weight at initial VP shunt insertion were found to be associated with shunt failure in the non-IVH group (p < .05). Of the 238 patients in the non-IVH cohort, 108 failed within 2 years of their initial insertion. Fifty of those shunt failures occurred within 3 months of initial shunt placement. In the IVH cohort, 56 out of 100 failed within 2 years; 36 of those failed within 3 months post initial shunt insertion. When controlling for type of shunt failure, age at initial shunt placement was associated with time to shunt failure (p = .0004).
This study confirms previously published studies on the IVH population. A prospective cohort study and standardized clinical decision making are necessary to further assess the impact that shunting has on this patient population.
先前的研究已对脑积水患儿分流失败的预测因素进行了调查,并得出结论,大多数分流装置无法长期使用。然而,病因、出生体重和胎龄等风险因素可能因机构和人群而异。我们试图确定与脑室内出血(IVH)患者群体以及病因不是IVH(非IVH)的患者群体中初始脑室腹腔(VP)分流失败相关的社会、临床和新生儿因素。
对2000年至2005年期间在阿拉巴马州儿童医院诊断和治疗脑积水的患者进行回顾性研究。生存分析确定了与分流失败时间相关的因素。
对IVH和非IVH队列分别进行分析。发现非IVH组中初次VP分流置入时的年龄和体重与分流失败相关(p <.05)。在非IVH队列的238例患者中,108例在初次置入后2年内失败。其中50例分流失败发生在初次分流置入后的3个月内。在IVH队列中,100例中有56例在2年内失败;其中36例在初次分流置入后3个月内失败。在控制分流失败类型时,初次分流置入时的年龄与分流失败时间相关(p =.0004)。
本研究证实了先前发表的关于IVH人群的研究。需要进行前瞻性队列研究和标准化的临床决策,以进一步评估分流对该患者群体的影响。