McInnes Elizabeth F, Ernst Heinrich, Germann Paul-Georg
Healthscope, Glenside, South Australia.
Toxicol Pathol. 2013 Jan;41(1):86-97. doi: 10.1177/0192623312448938. Epub 2012 Jun 15.
Male and female Syrian hamsters of the strain Han: AURA from the Fraunhofer Institute for Toxicology and Experimental Medicine breeding colony were maintained as control animals for five toxicity/carcinogenicity studies and were examined for the presence of neoplastic disease either when they died or when the study terminated. In total, 250 male animals and 250 female animals in three carcinogenicity studies were analyzed as well as the results of a 6-month study (fifty males and fifty females) and a 12-month study (fifty males and fifty females). In the 24-month studies, in the male animals, twenty-five organs were affected with malignant and benign tumors. In the female animals, twenty-four organs were affected with malignant and benign tumors. The most frequently affected tissue in the three 24-month studies was the adrenal gland where 141 cortical adenomas (56.4%) were noted in 250 male animals and 115 cortical adenomas (46%) noted in 250 female animals. In addition, a high incidence of squamous cell papilloma in the vagina was noted in female hamsters on the 24-month studies. A moderate incidence of squamous cell papilloma of the nonglandular forestomach, benign granulosa cell tumor of the ovary, lymphoma of the hemopoietic system, endometrial stromal polyp, and adenocarcinoma of the uterus and islet cell adenoma of the pancreas were also observed on the 24-month studies.
来自弗劳恩霍夫毒理学与实验医学研究所繁殖种群的Han:AURA品系的雄性和雌性叙利亚仓鼠，作为五个毒性/致癌性研究的对照动物，在其死亡或研究结束时检查是否存在肿瘤疾病。总共分析了三项致癌性研究中的250只雄性动物和250只雌性动物，以及一项6个月研究（50只雄性和50只雌性）和一项12个月研究（50只雄性和50只雌性）的结果。在24个月的研究中，雄性动物有25个器官受到恶性和良性肿瘤的影响。雌性动物有24个器官受到恶性和良性肿瘤的影响。在三项24个月的研究中，最常受影响的组织是肾上腺，在250只雄性动物中发现141个皮质腺瘤（56.4%），在25只雌性动物中发现115个皮质腺瘤（46%）。此外，在24个月的研究中，雌性仓鼠的阴道中鳞状细胞乳头瘤的发病率很高。在24个月的研究中还观察到非腺性前胃鳞状细胞乳头瘤、卵巢良性颗粒细胞瘤、造血系统淋巴瘤、子宫内膜间质息肉、子宫腺癌和胰腺胰岛细胞腺瘤的发病率中等。
