Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, USA.
Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine and The Rockefeller University, USA.
Lab Anim. 2021 Dec;55(6):560-567. doi: 10.1177/00236772211033672. Epub 2021 Aug 5.
A 14-month-old male Armenian hamster () presented with a spontaneous, subcutaneous, firm mass (4.0 × 2.0 × 1.5 cm) on the ventral neck extending towards the cheek pouch causing multifocal small oral ulcerations. This animal was immunized subcutaneously on the dorsal neck for the development of monoclonal antibodies seven months before presentation. The animal was euthanized and necropsy was performed. Histopathology of the mass showed a well demarcated, multilobulated, unencapsulated, highly cellular, neoplastic mass composed of spindle cells arranged in interlacing streams and bundles, with a moderate amount of fibrovascular stroma. The neoplastic cells exhibited indistinct cell borders and a moderate to large amount of eosinophilic, fibrillar cytoplasm, marked anisocytosis and anisokaryosis, binucleated and multinucleated cells, and high mitotic rate. Based on the histomorphologic features of the mass, and the presence of renal tubular hyaline globules and myeloid hyperplasia in the bone marrow, a diagnosis of histiocytic sarcoma was made. The presumptive diagnosis was confirmed by immunohistochemistry, upon which the neoplastic cells showed strong immunoreactivity for the histiocytic cell markers Iba1 and CD11b. Histiocytic sarcomas have been reported in Syrian () and Siberian dwarf () hamsters but, to our knowledge, the current report represents the first case of histiocytic sarcoma described in an Armenian hamster. It is plausible to consider the animal's experimental immunization history and the development of the histiocytic sarcoma to be related. An association between adjuvanted vaccines and soft-tissue sarcomas has been described in cats and referred to as feline injection-site sarcomas.
一只 14 个月大的雄性亚美尼亚仓鼠（）在颈部腹侧出现自发性、皮下、坚实的肿块（4.0×2.0×1.5 厘米），向颊囊延伸，导致多处小口腔溃疡。这只动物在出现症状前七个月在颈部背部接受了皮下免疫接种以开发单克隆抗体。该动物被安乐死并进行了解剖检查。肿块的组织病理学显示，边界清楚、多叶、无包膜、高度细胞性、由梭形细胞排列成交织的流和束组成的肿瘤，纤维血管基质含量中等。肿瘤细胞边界不明显，有中等至大量嗜酸性、纤维状细胞质，明显的大小不均和核异型性，双核和多核细胞，以及高有丝分裂率。基于肿块的组织形态学特征，以及骨髓中肾小管玻璃样小体和髓样细胞增生的存在，诊断为组织细胞肉瘤。免疫组织化学证实了初步诊断，肿瘤细胞对组织细胞标志物 Iba1 和 CD11b 表现出强烈的免疫反应性。组织细胞肉瘤已在叙利亚（）和西伯利亚侏儒（）仓鼠中报道，但据我们所知，目前的报告代表了在亚美尼亚仓鼠中描述的首例组织细胞肉瘤。可以认为动物的实验免疫史和组织细胞肉瘤的发展有关。在猫中已经描述了佐剂疫苗和软组织肉瘤之间的关联，并称为猫注射部位肉瘤。
