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法罗群岛的多发性硬化症以及幼儿期接触“多发性硬化症致病因子”可能产生的保护作用。

MS in the Faroe Islands and the possible protective effect of early childhood exposure to the "MS agent".

作者信息

Cooke R G

机构信息

Clarke Institute of Psychiatry, University of Toronto, Ontario, Canada.

出版信息

Acta Neurol Scand. 1990 Oct;82(4):230-3. doi: 10.1111/j.1600-0404.1990.tb01611.x.

Abstract

Epidemiologic data on multiple sclerosis (MS) in the Faroe Islands have been interpreted by the original investigators as supporting a particular infectious disease model. They suggest that MS occurs as a late consequence of extended exposure to an infectious agent which cannot be transmitted to subjects younger than 11 years of age. However, the Faroes data may better fit an alternate model, in which MS results from delayed primary exposure to an infectious agent which more commonly produces benign illness and protection against MS in subjects who are exposed in infancy or early childhood.

摘要

法罗群岛上多发性硬化症(MS)的流行病学数据被最初的研究人员解释为支持一种特定的传染病模型。他们认为,MS是长期接触一种无法传播给11岁以下人群的传染原的后期结果。然而,法罗群岛的数据可能更符合另一种模型,即MS是由于初次接触传染原的时间延迟所致,这种传染原通常会导致良性疾病,并且能使在婴儿期或幼儿期接触过的人对MS产生抵抗力。

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