Basquin S, Dubois M, Loukakis G, Maillot H, Mangenay L, Pacotte R, Questel R
Sem Hop. 1979;55(15-16):806-9.
An open, randomized clinical trial was carried out to compare the therapeutic efficacy of two products in the treatment of headaches. A total of 65 patients were prescribed tiapride and a similar number were given dimetotiazine (neuroleptic indicated in migraine and headache). Tiapride was prescribed as 3 tablets a day for the first 24 hours, followed by 1/2 a tablet three times daily. Excellent or good results (improvement of 60% or more), were obtained in 49 patients (75%). Results after dimetotiazine, at the recommended dosage of 2 capsules during the first 24 hours followed by 1 capsule at night, gave 30 excellent or good results (46%). There is a highly significant difference (p less than 0,01) in favour of tiapride. Both products were well-tolerated.
