Wittmann T, Vaxman F, Lambert A, Sanches O, Buliard G, Grenier J F
1. Université de Médecine, Szent-Györgyi Albert, I. Service de Médecine, Szeged, Hongrie.
Ann Chir. 1990;44(9):718-24.
The effect of prostaglandin E2 (PgE2) on the circular and longitudinal contractions of the canine colon was studied in chronic conditions. A mechanical transducer developed in our laboratory and implanted on the canine colon collected simultaneously and separately the variations of length in two perpendicular directions. The recordings started at the 6 postoperative day. The colonic motility was recorded two hours before (as control period) and two hours after the intravenous injection of PgE2 at three different doses: 0.1-1.0 and 10 micrograms/kg. PgE2, at the three doses, induced, progressively over time, a significant decrease in duration and amplitude of the circular contractions, while the amplitude of longitudinal contractions remained unchanged. 10 micrograms/kg of PgE2 immediately induced a significant increase in the duration of longitudinal contractions followed by a decrease in this value during the 2nd hour after PgE2 administration. Each dose of PgE2 shortened the period of recurrence of longitudinal contractions, inducing rapid or immediate bursts of contractions. This effect was moderate or absent for the circular contractions. It is concluded, that PgE2 has different actions on circular and longitudinal contractions of the colon. According to the dose used, it induces hypokinesia (relaxation) in the circular muscle and premature strong contractions in the longitudinal motor activity.
在慢性条件下研究了前列腺素E2（PgE2）对犬结肠环形和纵向收缩的影响。我们实验室研制的一种机械换能器植入犬结肠，同时分别收集两个垂直方向的长度变化。记录从术后第6天开始。在静脉注射三种不同剂量（0.1 - 1.0和10微克/千克）的PgE2前两小时（作为对照期）和后两小时记录结肠运动。三种剂量的PgE2随时间推移逐渐导致环形收缩的持续时间和幅度显著降低，而纵向收缩的幅度保持不变。10微克/千克的PgE2立即导致纵向收缩持续时间显著增加，随后在给药后第2小时该值下降。每种剂量的PgE2均缩短纵向收缩的复发周期，引发快速或立即的收缩爆发。这种效应在环形收缩中中等或不存在。得出结论，PgE2对结肠的环形和纵向收缩有不同作用。根据所用剂量，它可诱导环形肌运动减退（松弛）以及纵向运动活动过早出现强烈收缩。
