[Prevention of stress ulcers with sulpiride (author's transl)].

Stress ulcers or hemorrhagic lesions of the digestive tract may arise after multiple or cranial trauma, burns, frostbite, severe operations or intensive care treatment, respiratory of renal failure, or any other severe disorder affecting the body. The risk of a stress ulcer accurring varies from 10 to 50% according to the severity and number of factors involved. Sulpiride was studied to assess its preventive value, in 50 high-risk patients being treated in an intensive care unit for medical or surgical conditions. The dosage was 3 injectable ampoules daily during the whole period of intensive care treatment. Control investigations (endoscopy, gastric aspiration, autopsy in case of death) were carried out in all patients. No gastro-intestinal erosions or ulcers developed in any of the 50 patients, and no signs of intolerance were reported.