Heinkelein J
Sem Hop. 1979;55(19-20):973-6.
Stress ulcers or hemorrhagic lesions of the digestive tract may arise after multiple or cranial trauma, burns, frostbite, severe operations or intensive care treatment, respiratory of renal failure, or any other severe disorder affecting the body. The risk of a stress ulcer accurring varies from 10 to 50% according to the severity and number of factors involved. Sulpiride was studied to assess its preventive value, in 50 high-risk patients being treated in an intensive care unit for medical or surgical conditions. The dosage was 3 injectable ampoules daily during the whole period of intensive care treatment. Control investigations (endoscopy, gastric aspiration, autopsy in case of death) were carried out in all patients. No gastro-intestinal erosions or ulcers developed in any of the 50 patients, and no signs of intolerance were reported.
应激性溃疡或消化道出血性病变可能发生在多发性或颅脑创伤、烧伤、冻伤、大手术或重症监护治疗、呼吸或肾衰竭，或任何其他影响身体的严重疾病之后。根据所涉及因素的严重程度和数量，发生应激性溃疡的风险在10%至50%之间。对50例因内科或外科疾病在重症监护病房接受治疗的高危患者进行了研究，以评估舒必利的预防价值。在整个重症监护治疗期间，剂量为每日3支注射剂。对所有患者进行了对照检查（内镜检查、胃抽吸、死亡病例尸检）。50例患者中无一例发生胃肠道糜烂或溃疡，也未报告不耐受迹象。
