[癌基因、抗癌基因与致癌作用]
[Oncogenes, antioncogenes and carcinogenesis].
作者信息
Kopnin B P
出版信息
Arkh Patol. 1990;52(9):3-11.
PMID:2270978
Abstract
Current concepts on oncogenes, "antioncogenes" and their role in tumorigenesis are presented. Normal functions of proto-oncogenes, mechanisms of their conversion to oncogenes and inactivation of "antioncogenes", effects of oncogenes in model systems in vitro and in vivo are considered. Special attention is paid to the nonrandom proto-oncogene and "antioncogene" alterations in human tumours and the possibilities of their use as diagnostic or prognostic criteria.
摘要
本文介绍了关于癌基因、“抗癌基因”及其在肿瘤发生中作用的当前概念。探讨了原癌基因的正常功能、其转化为癌基因的机制以及“抗癌基因”的失活，还考虑了癌基因在体外和体内模型系统中的作用。特别关注了人类肿瘤中原癌基因和“抗癌基因”的非随机改变及其作为诊断或预后标准的可能性。
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