Schmidt J
Institute of Pharmacology and Toxicology, Medical Academy, Carl Gustav Carus, Dresden, GDR.
Biomed Biochim Acta. 1990;49(5):413-9.
In an attempt to characterize the anticonvulsant efficacy of nootropics, their effect on different types of kindled seizures in rats has been studied. Nootropics in doses known to have protective effects in damaged brain functions possess anticonvulsant potency preferentially in pentylenetetrazole (PTZ)-kindled rats and generalized seizures. The most pronounced potency was seen in PTZ-kindled rats, where all substances tested (piracetam, meclofenoxate, pyritinol, vinpocetine, methylglucamine orotate, naftidrofuryl) led to significant dose-dependent anticonvulsant effects. In amygdala-kindled rats only vinpocetine, meclofenoxate and piracetam were effective. In neocortically kindled rats only vinpocetine and, to a smaller extent, pyritinol showed anticonvulsant effects. The data support the potential antiepileptic potency of nootropics.
为了描述促智药的抗惊厥功效，研究了它们对大鼠不同类型点燃性癫痫发作的影响。已知对受损脑功能具有保护作用剂量的促智药，在戊四氮（PTZ）点燃的大鼠和全身性癫痫发作中优先具有抗惊厥效力。在PTZ点燃的大鼠中观察到最显著的效力，其中所有测试物质（吡拉西坦、甲氯芬酯、吡硫醇、长春西汀、乳清酸葡甲胺、萘呋胺酯）均产生显著的剂量依赖性抗惊厥作用。在杏仁核点燃的大鼠中，只有长春西汀、甲氯芬酯和吡拉西坦有效。在新皮质点燃的大鼠中，只有长春西汀以及在较小程度上吡硫醇显示出抗惊厥作用。这些数据支持了促智药的潜在抗癫痫效力。
