Schmidt J
Institute of Pharmacology and Toxicology, Medical Academy Carl Gustav Carus, Dresden, GDR.
Biomed Biochim Acta. 1990;49(1):133-6.
In an attempt to identify the functional role of cerebral dopaminergic processes for the action of nootropic drugs the influence of piracetam, meclofenoxate, pyritinol, vinpocetine and methylglucamine orotate on apomorphine-induced stereotyped behaviour was studied. Meclofenoxate, pyritinol, vinpocetine and methylglucamine orotate enhanced significantly the apomorphine-elicited stereotypy in rats without triggering the behaviour itself. Piracetam (300, 500 or 1000 mg/kg ip.) was ineffective in this test. These results support the assumption that the functional activation of cerebral aminergic processes plays a possible role in the mode of action of some typical representatives of nootropic drugs.
为了确定脑多巴胺能过程在促智药作用中的功能作用，研究了吡拉西坦、氯酯醒、吡硫醇、长春西汀和乳清酸甲基葡胺对阿扑吗啡诱导的刻板行为的影响。氯酯醒、吡硫醇、长春西汀和乳清酸甲基葡胺显著增强了阿扑吗啡诱发的大鼠刻板行为，而未引发行为本身。吡拉西坦（腹腔注射300、500或1000mg/kg）在该试验中无效。这些结果支持了这样一种假设，即脑胺能过程的功能激活在一些典型促智药的作用方式中可能起作用。
