BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg 79104, Germany.
FEBS Lett. 2012 Jul 4;586(14):1921-8. doi: 10.1016/j.febslet.2012.03.063. Epub 2012 Apr 9.
The physiological responses to TGF-β stimulation are diverse and vary amongst different cell types and environmental conditions. Even though the principal molecular components of the canonical and the non-canonical TGF-β signaling pathways have been largely identified, the mechanism that underlies the well-established context dependent physiological responses remains a mystery. Understanding how the components of TGF-β signaling function as a system and how this system functions in the context of the global cellular regulatory network requires a more quantitative and systematic approach. Here, we review the recent progress in understanding TGF-β biology using integration of mathematical modeling and quantitative experimental analysis. These studies reveal many interesting dynamics of TGF-β signaling and how cells quantitatively decode variable doses of TGF-β stimulation.
TGF-β 刺激的生理反应是多种多样的，并且在不同的细胞类型和环境条件下有所不同。尽管经典和非经典 TGF-β 信号通路的主要分子成分已经被广泛确定，但基础生理反应背后的机制仍然是个谜。要了解 TGF-β 信号的组成部分如何作为一个系统发挥作用，以及该系统如何在全局细胞调控网络的背景下发挥作用，需要更定量和系统的方法。在这里，我们回顾了使用数学建模和定量实验分析相结合来理解 TGF-β 生物学的最新进展。这些研究揭示了 TGF-β 信号的许多有趣动态，以及细胞如何定量解码 TGF-β 刺激的不同剂量。
