GéPITOs, Université de Nice, CNRS UMR 6235, UFR Médecine, 28 avenue de Valombrose, 06107 Nice Cedex 2, France.
Drug Discov Today. 2012 Oct;17(19-20):1127-32. doi: 10.1016/j.drudis.2012.06.007. Epub 2012 Jun 16.
Gallium (Ga) is a semi-metallic element that displays antitumor, antiresorptive, anti-inflammatory and immunosuppressive properties. Among all these properties, antitumor properties were the most extensively applied and have shown efficacy in treatment of Paget's disease, myeloma and hypercalcemia in cases of malignancy. By contrast, no clinical trials have been conducted in prevention and/or treatment of osteoporosis. In this article I focus on Ga effects on bone tissue and cells, as well as on molecular mechanisms governing Ga internalization into cells. Eventually, the potential of Ga as an antiosteoporotic agent is discussed.
镓（Ga）是一种半金属元素，具有抗肿瘤、抗吸收、抗炎和免疫抑制特性。在所有这些特性中，抗肿瘤特性的应用最为广泛，并已在治疗 Paget 病、骨髓瘤和恶性肿瘤高钙血症方面显示出疗效。相比之下，尚无临床试验用于预防和/或治疗骨质疏松症。本文重点介绍 Ga 对骨组织和细胞的影响，以及控制 Ga 进入细胞的分子机制。最后，讨论了 Ga 作为一种抗骨质疏松药物的潜力。
