University of Texas Medical School at Houston, 77630, USA.
Curr Atheroscler Rep. 2012 Aug;14(4):360-5. doi: 10.1007/s11883-012-0261-0.
Cavernous Malformations (CMs) are immature vessels consisting of endothelium-lined sinusoids. Often diagnosed incidentally, they remain clinically silent in the vast majority of patients. Their natural history is now largely believed to follow a benign course that should be conservatively managed in the majority of cases. The exception is the treatment of deep lesions. Here there is not a consensus but the general inclination is towards radiosurgical treatment of inaccessible lesions. However, the results of radiosurgical or gross surgical resection have not been shown to be significantly better than many patients who were managed conservatively. In view of this, an understanding of the natural history of CM and the various outcomes from surgery, radiosurgery and conservative management are essential to define the goals for patients and to individualize treatment strategy.
海绵状血管畸形（CMs）是由内皮细胞衬里的窦组成的不成熟血管。它们通常是偶然诊断出来的，在绝大多数患者中保持临床无症状。现在普遍认为，其自然病程呈良性，在大多数情况下应采用保守治疗。例外情况是治疗深部病变。在这里，目前还没有共识，但一般倾向于对无法到达的病变进行放射外科治疗。然而，放射外科或大体手术切除的结果并没有明显优于许多采用保守治疗的患者。鉴于此，了解 CM 的自然病史以及手术、放射外科和保守治疗的各种结果对于确定患者的目标和制定个体化治疗策略至关重要。
