L-样5'-去甲阿霉素的脱氧衍生物
Deoxy Derivatives of L-like 5'-Noraristeromycin.
作者信息
Hinton Shante, Riddick Alecia, Serbessa Tesfaye
机构信息
Elizabeth City State University, Department of Chemistry, Geology, and Physics, Elizabeth city, NC 27909.
出版信息
Tetrahedron Lett. 2012 Apr;53(14):1753-1755. doi: 10.1016/j.tetlet.2012.01.101. Epub 2012 Feb 2.
Abstract
Several base variations of 2'- and 3'-deoxy derivatives of (+)-4'-deoxy-5'-noraristeromycin have been prepared from enantiomerically pure precursors following standard purine nucleoside construction. These carbocyclic nucleosides were evaluated against hepatitis B virus (HBV) and found to be inactive. No cytotoxicity to the cell line was observed.
摘要
按照标准嘌呤核苷构建方法，从对映体纯的前体出发，制备了(+)-4'-脱氧-5'-去甲阿瑞司他霉素的几种2'-和3'-脱氧衍生物的碱基变体。对这些碳环核苷进行了抗乙型肝炎病毒（HBV）评估，发现它们没有活性。未观察到对细胞系的细胞毒性。
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本文引用的文献
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Carbocyclic nucleosides as inhibitors of human tumor necrosis factor-alpha production: effects of the stereoisomers of (3-hydroxycyclopentyl)adenines.碳环核苷作为人肿瘤坏死因子-α产生的抑制剂：(3-羟基环戊基)腺嘌呤立体异构体的作用
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