L-样5'-去氧阿瑞吡坦的N-6取代脱氧衍生物
N-6 Substituted Deoxygenated Derivatives of L-like 5'-Noraristeromycin.
作者信息
Yu Henry, Serbessa Tesfaye
机构信息
Elizabeth City State University, Department of Chemistry, Geology, and Physics Elizabeth city, NC 27909 USA.
出版信息
Bull Chem Soc Ethiop. 2010;24(3):439-446. doi: 10.4314/bcse.v24i3.60692.
Abstract
Several N-6 substituted derivatives (4-11) of (+)-4'-deoxy-5'-noraristeromycin (2) and its unsaturated counterpart (3) have been prepared. The derivatives are designed to systematically vary the hydrophobic/hydrophilic balance of the lead compounds. These compounds were evaluated against a large number of viruses but, no significant antiviral activity was observed. Also, no cytotoxicity to host cells was found.
摘要
已制备了几种（+）-4'-脱氧-5'-去甲阿瑞司他霉素（2）及其不饱和类似物（3）的N-6取代衍生物（4-11）。设计这些衍生物是为了系统地改变先导化合物的疏水/亲水平衡。对这些化合物针对大量病毒进行了评估，但未观察到明显的抗病毒活性。此外，未发现对宿主细胞的细胞毒性。
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本文引用的文献
1
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2
Carbocyclic nucleosides (carbanucleosides) as new therapeutic leads.
Curr Top Med Chem. 2002 Oct;2(10):1087-92. doi: 10.2174/1568026023393228.
3
Safety and efficacy of oral entecavir given for 28 days in patients with chronic hepatitis B virus infection.口服恩替卡韦治疗慢性乙型肝炎病毒感染患者28天的安全性和有效性。
Hepatology. 2001 Sep;34(3):578-82. doi: 10.1053/jhep.2001.26815.
4
Lamivudine as initial treatment for chronic hepatitis B in the United States.在美国，拉米夫定作为慢性乙型肝炎的初始治疗药物。
N Engl J Med. 1999 Oct 21;341(17):1256-63. doi: 10.1056/NEJM199910213411702.
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6
The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial.阿德福韦酯（一种新型抗人类免疫缺陷病毒（HIV）疗法）在HIV感染成人中的安全性和有效性：一项随机、双盲、安慰剂对照试验。
J Infect Dis. 1997 Dec;176(6):1517-23. doi: 10.1086/514150.
7
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N Engl J Med. 1997 Dec 11;337(24):1733-45. doi: 10.1056/NEJM199712113372406.
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