Chumachenko P V, Belokon' E V, Akchurin R S, Zhdanov V S
Arkh Patol. 2012 Jan-Feb;74(1):3-6.
Unstable atherosclerotic plaques are a cause of acute myocardium infarction. Because peripheral blood mononuclear cells are often present in atherosclerotic plaques, we've examined T-cells (CD4, CD8) and macrophages (CD68) in the different areas of atherosclerotic plaques. The cells were counted individually in the center, shoulder at the bottom and in the cap of plaque. All types of studied cells prevailed in the unstable plaque cap than in the stable one (p < 0.05). CD4 and CD68 cells dominated in the shoulder of atherosclerotic plaque (p < 0.05). The difference between the numbers of macrophages at the bottom or in the center of stable and unstable plaques was statistically insignificant (p > 0.05). Prevalence of peripheral blood mononuclears in the cap and at the periphery of unstable plaques points their participation in the development of atherosclerotic plaque instability.
不稳定的动脉粥样硬化斑块是急性心肌梗死的一个病因。由于外周血单核细胞常存在于动脉粥样硬化斑块中，我们检测了动脉粥样硬化斑块不同区域的T细胞（CD4、CD8）和巨噬细胞（CD68）。分别对斑块中心、底部肩部和帽部的细胞进行计数。与稳定斑块相比，所有类型的研究细胞在不稳定斑块帽部更为常见（p<0.05）。CD4和CD68细胞在动脉粥样硬化斑块肩部占主导（p<0.05）。稳定斑块和不稳定斑块底部或中心的巨噬细胞数量差异无统计学意义（p>0.05）。外周血单核细胞在不稳定斑块帽部和周边的存在表明它们参与了动脉粥样硬化斑块不稳定性的发展。
