Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Suruga-ku, Shizuoka, Japan.
Nat Prod Res. 2013;27(9):775-81. doi: 10.1080/14786419.2012.698412. Epub 2012 Jun 19.
The new siderophore tsukubachelin B (1) was isolated from the iron-deficient culture medium of the newly isolated strain Streptomyces sp. TM-74. The chemical structure of tsukubachelin B (1) was established via interpretation of 2D nuclear magnetic resonance and electrospray ionization-mass spectroscopic data. The structure of tsukubachelin B (1) comprises 6 mol of amino acids, including 2 mol of serine and 1 mol each of ornithine, N-α-methyl-N-δ-hydroxy-N-δ-formylornithine, N-α-methyl-N-δ-hydroxyornithine, and cyclic N-hydroxyornithine.
新型铁载体 tsukubachelin B（1）从新分离的链霉菌属 TM-74 的缺铁培养基中分离得到。tsukubachelin B（1）的化学结构通过二维核磁共振和电喷雾电离质谱数据的解析得以确定。tsukubachelin B（1）的结构由 6 个氨基酸组成，包括 2 个丝氨酸和 1 个每个的鸟氨酸、N-α-甲基-N-δ-羟基-N-δ-甲酰基鸟氨酸、N-α-甲基-N-δ-羟基鸟氨酸和环状 N-羟基鸟氨酸。
