海洋来源链霉菌 sp. YM5-799 产生的三羟基苯甲酰基类铁载体链霉胍菌素。

Streptobactin, a tricatechol-type siderophore from marine-derived Streptomyces sp. YM5-799.

机构信息

Suntory Holdings Ltd. , Yamazaki, Shimamoto, Mishima, Osaka 618-0001, Japan.

出版信息

J Nat Prod. 2011 Nov 28;74(11):2371-6. doi: 10.1021/np200290j. Epub 2011 Oct 20.

DOI:10.1021/np200290j

PMID:22014204

Abstract

A new catechol-type siderophore, streptobactin (1), was isolated from a culture broth of the marine-derived actinomycete Streptomyces sp. YM5-799. The structure of streptobactin was determined by NMR and MS analyses and ESIMS/MS experiments to be a cyclic trimer of benarthin. A dibenarthin (2), a tribenarthin (3), and benarthin (4) were also obtained. The production of 1 was regulated by an iron concentration in the culture. The iron-chelating activity of the compounds was evaluated by the chrome azurol sulfonate assay.

摘要

从海洋来源放线菌 Streptomyces sp. YM5-799 的发酵液中分离得到一种新的儿茶酚型铁载体，链丝菌素（1）。通过 NMR 和 MS 分析以及 ESIMS/MS 实验确定链丝菌素的结构为苯并噻嗪的环状三聚体。还得到了二苯并噻嗪（2）、三苯并噻嗪（3）和苯并噻嗪（4）。1 的产量受培养物中铁浓度的调节。通过铬天青 S 比色法评估了化合物的铁螯合活性。