Ruiz-Cabello J M, Pérez de las Vacas B J, Rosado G M, González N M
Hospital de la SS San Pedro de Alcántara, Cáceres.
Rev Esp Enferm Dig. 1990 Aug;78(2):93-5.
Primary malignant melanoma of the esophagus is very rare, and only 139 cases have been described in all the world literature. We present one case of primary malignant melanoma of the esophagus in a 76-year-old woman who reported the symptoms of dysphagia and recent weight loss; the radiography showed a large polypoid mass filling the entire lower half of the esophagus, dark brown-black in the endoscopy. Histologic analysis demonstrated the existence of a malignant melanoma infiltrating the esophageal mucosa, composed of anaplastic cells with abundant brown pigment which had positive immunoreactivity for the S-100 protein.
原发性食管恶性黑色素瘤非常罕见，全世界文献中仅报道过139例。我们报告一例76岁女性原发性食管恶性黑色素瘤病例，该患者有吞咽困难和近期体重减轻的症状；影像学检查显示一个大的息肉样肿物充满食管下半部，内镜检查时呈深棕黑色。组织学分析显示存在浸润食管黏膜的恶性黑色素瘤，由具有丰富棕色色素的间变细胞组成，这些细胞对S-100蛋白呈阳性免疫反应。
