Benito Sánchez F G, Jiménez Pérez C, González Arias R, Sáez García M A, García Benavente A, Montero Vázquez J M
Servicio de Aparato Digestivo, Hospital Militar Central Gómez-Ulla, Madrid.
Gastroenterol Hepatol. 1998 Jun-Jul;21(6):283-6.
Primary malignant melanoma of the esophagus is an extremely rare non-epithelial neoplasm with a fatal prognosis. At present, approximately 184 cases have been published in the world literature. Of all published cases, 10 (5.4%) occurred in Spain. A 76 year-old man with malignant melanoma of the esophagus presented with dysphagia and weight loss, and treated by subtotal esophageal resection is reported. There was no history of previous cutaneous melanoma and ophthalmologic examination had been normal. At esophagoscopy a polypoid and pigmented mass (diameter 5 cm) almost completely occluding the lumen in the lower third of the esophagus was found. Multiple tumor biopsies were obtained. Histological diagnoses were made by examining endoscopic biopsy specimens and confirmed with resected specimens. The purpose of this communication is to present a case of primary esophageal malignant melanoma proved preoperatively by histological and immunohistochemical studies (positive reaction to the HMB-45 and S-100 antigen), followed by a review of the literature of these exceptional tumors.
原发性食管恶性黑色素瘤是一种极其罕见的非上皮性肿瘤，预后不良。目前，世界文献中已发表约184例。在所有已发表的病例中，10例（5.4%）发生在西班牙。本文报道了一名76岁食管恶性黑色素瘤男性患者，表现为吞咽困难和体重减轻，接受了食管次全切除术治疗。患者既往无皮肤黑色素瘤病史，眼科检查正常。食管镜检查发现一个息肉样色素沉着肿物（直径5 cm），几乎完全阻塞食管下三分之一的管腔。获取了多个肿瘤活检标本。通过检查内镜活检标本进行组织学诊断，并经切除标本证实。本文旨在介绍一例经组织学和免疫组化研究术前确诊的原发性食管恶性黑色素瘤病例（对HMB - 45和S - 100抗原呈阳性反应），并对这些罕见肿瘤的文献进行综述。
