Department of Molecular Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-Ku, Nagoya, Japan.
Biochimie. 2012 Oct;94(10):2137-42. doi: 10.1016/j.biochi.2012.06.008. Epub 2012 Jun 17.
Obesity-related disorders, such as insulin resistance, hypertension and atherosclerosis, are associated with chronic inflammation. Adiponectin is an adipocyte-derived secreted factor that is down-regulated in obese states. Adiponectin exerts the protective actions on obesity-linked diseases, such as insulin resistance and atherosclerosis by attenuating chronic inflammation in its target organs. Adiponectin also exerts the salutary effects on vascular disorders by directly acting on vascular component cells including endothelial cells, smooth muscle cells and macrophages. This review will focus on the role of adiponectin in control of inflammatory responses and atherogenic processes.
肥胖相关疾病，如胰岛素抵抗、高血压和动脉粥样硬化，与慢性炎症有关。脂联素是一种脂肪细胞分泌的因子，在肥胖状态下下调。脂联素通过减轻其靶器官的慢性炎症，对与肥胖相关的疾病（如胰岛素抵抗和动脉粥样硬化）发挥保护作用。脂联素还通过直接作用于血管成分细胞，包括内皮细胞、平滑肌细胞和巨噬细胞，对血管紊乱发挥有益作用。这篇综述将重点讨论脂联素在控制炎症反应和动脉粥样硬化形成过程中的作用。
