Taura S, Taura M, Kamio A, Kummerow F A
Tohoku J Exp Med. 1979 Sep;129(1):9-16. doi: 10.1620/tjem.129.9.
Coronary atherosclerosis developed in normolipemic swine fed a basal ration supplemented with 125,000 IU, 62,500 IU and 31,250 IU of vitamin D3/kg of diet for 3 months and subsequently only the basal ration for the following 3 months. Lesions consisted of intimal atheromata and calcified internal elastica and caused luminal narrowing. The incidence of atherosclerotic lesions was proportional to the vitamin D3 doses. The present experimentally induced lesions had many morphological features resembling those in coronary arteries from human subjects.
在给正常血脂的猪喂食添加了每千克日粮125,000国际单位、62,500国际单位和31,250国际单位维生素D3的基础日粮3个月，随后在接下来的3个月仅喂食基础日粮的情况下，冠状动脉粥样硬化形成。病变包括内膜粥样瘤和钙化的内弹力层，并导致管腔狭窄。动脉粥样硬化病变的发生率与维生素D3剂量成正比。目前实验诱导的病变具有许多类似于人类冠状动脉病变的形态学特征。
