Toda T, Ito M, Toda Y, Smith T, Kummerow F
Food Chem Toxicol. 1985 Jun;23(6):585-92. doi: 10.1016/0278-6915(85)90183-8.
The effects of five different dietary levels of vitamin D3 on the coronary arteries of groups of 17-60 2-month old weanling Yorkshire swine were studied. Four groups were fed the following levels of vitamin D3 per ton of ration continuously for 4 months: group I--100,000 IU, group II--300,000 IU, group IV--2,000,000, and group V--4,000,000 IU. Swine in group III were fed the diet containing 100,000 IU of vitamin D3 per ton of ration for the first 2 months of the study after which they were fed a diet supplemented with 4,000,000 IU of vitamin D3 per ton of ration for the remaining 2 months of the study. The highest degree of intimal thickening of the coronary arteries was observed among group V. The thickened areas contained numerous lipid-containing cells and degenerate cells without stainable lipid. Electron microscopic examination revealed a greater frequency of degenerate cells without stainable lipid in the coronary arteries of groups III and IV than in groups I and II. These results suggest a possible link between excessive daily intake of vitamin D3 and the development of human coronary atherosclerosis.
研究了五种不同膳食水平的维生素D3对17 - 60头2月龄断奶约克夏仔猪冠状动脉的影响。四组仔猪连续4个月按每吨日粮投喂以下水平的维生素D3：第一组——100,000国际单位，第二组——300,000国际单位，第四组——2,000,000国际单位，第五组——4,000,000国际单位。第三组仔猪在研究的前2个月按每吨日粮投喂含100,000国际单位维生素D3的日粮，之后在研究的剩余2个月投喂每吨日粮添加4,000,000国际单位维生素D3的日粮。冠状动脉内膜增厚程度最高的是第五组。增厚区域含有大量含脂质细胞和无脂质可染的退变细胞。电子显微镜检查显示，第三组和第四组仔猪冠状动脉中无脂质可染的退变细胞出现频率高于第一组和第二组。这些结果表明，每日过量摄入维生素D3与人类冠状动脉粥样硬化的发生可能存在联系。
