Rylander R, Sjöstrand M, Bergström R
Toxicology. 1979 Mar-Apr;12(3):211-20. doi: 10.1016/0300-483x(79)90067-2.
Guinea pigs were acutely exposed to different airborne dusts and freshly generated cigarette smoke. The effect was evaluated by counting the number of free lung cells using a lavage method. An exposure to MnO2 and smoke on the same day caused an increase in the number of leukocytes 24 h thereafter. By increasing the time interval between the MnO2 and smoke exposure, the effect gradually disappeared. Al2O2 or SiO2 also caused an increase in the number of leukocytes, whereas TiO2 had no effect. The pathogenesis behind the reaction and the epidemiological implications are discussed.
将豚鼠急性暴露于不同的空气传播粉尘和新产生的香烟烟雾中。通过灌洗法计数游离肺细胞的数量来评估其效果。同一天暴露于二氧化锰和烟雾中会导致24小时后白细胞数量增加。通过增加二氧化锰暴露和烟雾暴露之间的时间间隔，这种效果逐渐消失。氧化铝或二氧化硅也会导致白细胞数量增加，而二氧化钛则没有效果。讨论了该反应背后的发病机制和流行病学意义。
